Atea says Phase 3 CBEYOND trial hits endpoints, with BEM/RZR posting 93.9% SVR at Week 24

AI Market Summary
Atea Pharmaceuticals reported positive topline Phase 3 CBEYOND results for bemnifosbuvir/ruzasvir in chronic HCV, meeting primary and secondary endpoints with statistical noninferiority versus sofosbuvir/velpatasvir and demonstrating strong 8-week cure rates in non-cirrhotic patients. The readout reduces late-stage development uncertainty and supports a differentiated clinical profile, which can improve perceived probability of regulatory success. Broader market spillover appears limited.
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Atea Pharmaceuticals said its hepatitis C regimen bemnifosbuvir/ruzasvir met both the primary and secondary endpoints in the North America Phase 3 C-BEYOND trial. In the modified intent-to-treat population, the sustained virologic response rate was 93.9%, statistically noninferior to 94.8% for sofosbuvir/velpatasvir. Among patients without cirrhosis, an 8-week course of bemnifosbuvir/ruzasvir achieved a 93.5% cure rate.